Article

Fucosylation Enhances CD34⁺ Hematopoietic Stem Cell Homing and Longevity via E-Selectin–Mediated Adhesion and Signaling

2025-11-26

Abstract excerpt

<title>Abstract</title> <p>Background Hematopoietic stem cell transplantation (HSCT) is a cornerstone treatment for blood disorders and hematological malignancies, although its efficacy is limited by inefficient stem cell homing to the bone marrow. We previously demonstrated that fucosylated HSC ligands interact with endothelial E-selectin to facilitate homing. However, the downstream consequences of modulating f...

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Literature Corpus work: 28d75c6b-dcc7-5870-b2fe-7eac10b9c568
DOI: 10.21203/rs.3.rs-7961408/v1

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