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A Glycovariant of Human CD44 is Characteristically Expressed on Human Mesenchymal Stem Cells

26 Nov 2016

Abstract excerpt

Abstract The clinical effectiveness of systemically administered human mesenchymal stem cells (hMSCs) depends on their capacity to engage vascular endothelium. hMSCs derived from bone marrow (BM-hMSCs) natively lack endothelial binding capacity, but express a CD44 glycovariant containing N-linked sialyllactosamines that can be α(1,3)-fucosylated using fucosyltransferase-VI (FTVI) to enforce sLeX decorations,...

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PMID: 27888602
DOI: 10.1002/stem.2549

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