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Article

Deficiency of core fucosylation activates cellular signaling dependent on FLT3 expression in a Ba/F3 cell system.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2020

Duan Chengwei, Fukuda Tomohiko, Isaji Tomoya, Qi Feng, Yang Jie, Wang Yuqin, Takahashi Shinichiro, Gu Jianguo

Abstract excerpt

Fms-like tyrosine kinase 3 (FLT3) is a glycoprotein, that is a member of the class III receptor tyrosine kinase family. Approximately one-third of acute myeloid leukemia (AML) patients have mutations of this gene, and activation of the FLT3 downstream pathway plays an important role in both normal and malignant hematopoiesis. However, the role of N-glycosylation for FLT3 activation remains unclear. In this study,...

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PMID: 31908039
DOI: 10.1096/fj.201902313RR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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