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PDIM drives the transition from repairable to catastrophic EsxA-mediated vacuole membrane damage during <i>Mycobacterium marinum</i> infection

2026-05-27

Abstract excerpt

During infection, pathogenic mycobacteria damage the membrane of the Mycobacterium -containing vacuole (MCV), triggering host repair responses that preserve an intracellular permissive niche before bacteria escape to the cytosol at later stages. How the MCV transitions from repairable injury to catastrophic rupture remains poorly understood. Here, we dissected the respective contributions of the ESX-1 effectors E...

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Literature Corpus work
28beae38-867f-553d-a6a6-cc756547d681
DOI
10.64898/2026.05.27.728140
Open publication

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