Article
High microbiota reactivity of adult human intestinal IgA requires somatic mutations.
The Journal of experimental medicine - 2 Nov 2020
Kabbert Johanna, Benckert Julia, Rollenske Tim, Hitch Thomas C A, Clavel Thomas, Cerovic Vuk, Wardemann Hedda, Pabst Oliver
Abstract excerpt
The gut is home to the body's largest population of plasma cells. In healthy individuals, IgA is the dominating isotype, whereas patients with inflammatory bowel disease also produce high concentrations of IgG. In the gut lumen, secretory IgA binds pathogens and toxins but also the microbiota. However, the antigen specificity of IgA and IgG for the microbiota and underlying mechanisms of antibody binding to...
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