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IgG and IgM cooperate in coating of intestinal bacteria in IgA deficiency

8 Dec 2023

Abstract excerpt

Immunoglobulin A (IgA) is acknowledged to play a role in the defence of the mucosal barrier by coating microorganisms. Surprisingly, IgA-deficient humans exhibit few infection-related complications, raising the question if the more specific IgG may help IgM in compensating for the lack of IgA. Here we employ a cohort of IgA-deficient humans, each paired with IgA-sufficient household members, to investigate...

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PMID: 38065985
DOI: 10.1038/s41467-023-44007-2

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