Article
Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12).
Blood - 1 Feb 1999
Chase A, Reiter A, Burci L, Cazzaniga G, Biondi A, Pickard J, Roberts I A, Goldman J M, Cross N C
Abstract excerpt
The t(12;13)(p13;q12) is a rare, recurrent translocation reported in a range of hematological malignancies. We have analyzed the molecular basis of this lesion in three patients with acute myeloid leukemia (AML), two of whom were known to have chromosome 12 breakpoints within the ETV6 gene. Fluorescence in situ hybridization (FISH) with ETV6 cosmids indicated that this gene was also disrupted in the third...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
