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Article

Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

15 May 1993

Abstract excerpt

Chromosome translocations involving band 11q23 are associated with human acute leukemias. These translocations fuse the ALL-1 gene, homolog of Drosophila trithorax and located at chromosome band 11q23, to genes from a variety of chromosomes. We cloned and sequenced cDNAs derived from transcripts of the AF-4 and AF-9 genes involved in the most common chromosome abnormalities, t(4:11)(q21:q23) and t(9:11)(p22:q23),...

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Identifiers

PMID: 8506309
DOI: 10.1073/pnas.90.10.4631

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.PMID 8506309Read ↗

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 geneSemantic proximity Read ↗

Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.Semantic proximity Read ↗

A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cellsSemantic proximity Read ↗

The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia.Semantic proximity Read ↗

The (4;11)(q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase.Semantic proximity Read ↗

Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia.Semantic proximity Read ↗

Exon/intron structure of the human ALL‐1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemiasSemantic proximity Read ↗

Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithoraxSemantic proximity Read ↗

Exon/intron structure of the human <i>AF‐4</i> gene, a member of the <i>AF</i>‐4/<i>LAF</i>‐4/<i>FMR</i>‐2 gene family coding for a nuclear protein with structural alterations in acute leukaemiaSemantic proximity Read ↗

LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemiasSemantic proximity Read ↗

Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: Almost identical MLL breakpoints in therapy‐related AML after treatment without etoposidesSemantic proximity Read ↗

DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesisSemantic proximity Read ↗

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