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Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration

2023-09-29

Abstract excerpt

Unchecked, chronic inflammation is a constitutive component of age-related diseases, including age-related macular degeneration (AMD). Here we identified interleukin-1 receptor-associated kinase (IRAK)-M as a key immunoregulator in retinal pigment epithelium (RPE) that declines with age. Rare genetic variants of IRAK-M increased the likelihood of AMD. IRAK-M expression in RPE declined with age or oxidative stress...

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Identifiers and source

Literature Corpus work
28697b04-0958-5d58-b23d-72c4aab5912e
DOI
10.1101/2023.09.27.559733
Open publication

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Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal DegenerationDOI 10.1101/2023.09.27.559733
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