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Article

The reduction of XIAP is associated with inflammasome activation in RPE: implications for AMD pathogenesis

22 Aug 2019

Abstract excerpt

BACKGROUND: Age-related macular degeneration (AMD) is a multifactorial chronic disease of the eye. Several candidate pathways have been hypothesized to play a role in AMD pathogenesis. Our work and those of others suggests inflammasome activity as a mechanism associated with retinal pigment epithelial (RPE) cell demise. X-linked inhibitor of apoptosis protein (XIAP), an anti-apoptosis factor, has recently been...

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Share to Cell death mechanisms and regulation
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PMID: 31438981
DOI: 10.1186/s12974-019-1558-5

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