Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration

5 Jun 2024

Abstract excerpt

Chronic inflammation is a constitutive component of many age-related diseases, including age-related macular degeneration (AMD). Here, we identified interleukin-1 receptor–associated kinase M (IRAK-M) as a key immunoregulator in retinal pigment epithelium (RPE) that declines during the aging process. Rare genetic variants ofIRAK3, which encodes IRAK-M, were associated with an increased likelihood of developing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38838135
DOI: 10.1126/scitranslmed.adi4125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degenerationPMID 38838135Read ↗

Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal DegenerationSemantic proximity Read ↗

Age-Related Macular Degeneration: A Disease of Cellular Senescence and Dysregulated Immune HomeostasisSemantic proximity Read ↗

Age-Related Macular Degeneration: Cellular and Molecular Signaling MechanismsSemantic proximity Read ↗

The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasomeSemantic proximity Read ↗

IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative DiseasesSemantic proximity Read ↗

Macrophage immunosenescence prolongs intraocular inflammation in aged mice via impaired induction of regulatory T cellsSemantic proximity Read ↗

Retinal aging transcriptome and cellular landscape in association with the progression of age-related macular degenerationSemantic proximity Read ↗

Retinal Aging Transcriptome and Cellular Landscape in Association With the Progression of Age-Related Macular DegenerationSemantic proximity Read ↗

NLRP3 Inflammasome and Pathobiology in AMDSemantic proximity Read ↗

Inflammatory priming predisposes mice to age-related retinal degenerationSemantic proximity Read ↗

Retinal pigment epithelium-derived PD-L1 reprograms microglial cells and protects against retinal degeneration in mouse models of experimental AMD and genetic retinitis pigmentosaSemantic proximity Read ↗

Accelerated aging phenotypes in the retinal pigment epithelium of Zmpste24-deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.