Article

A multidisciplinary approach towards identification of novel antibiotic scaffolds for <i>Acinetobacter baumannii</i>

2018-04-22

Abstract excerpt

Research efforts to discover potential new antibiotics for Gram-negative bacteria suffer from high attrition rates due to the synergistic action of efflux systems and the limited permeability of the outer membrane (OM). One potential strategy to overcome the OM permeability barrier is to identify small molecules that are natural substrates for abundant OM channels, and to use such compounds as scaffolds for the de...

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Literature Corpus work: 2863af53-294a-5e86-888f-0b3fe4885a19
DOI: 10.1101/306035

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