Article

Peptidisc-assisted hydrophobic clustering towards the production of multimeric and multispecific nanobody proteins

2025-01-01

Abstract excerpt

Protein multimerization is a powerful engineering strategy for enhancing structural stability, diversity and functional performance. Typical methods to cluster proteins include tandem linking, fusion to self-assembly domains and cross-linking. We present here an approach that leverages the peptidisc membrane mimetic to stabilize hydrophobic-driven protein associations. We apply the method to nanobodies (Nbs), effe...

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Literature Corpus work: 0ff7283b-5172-5ed4-bb73-1de56a7a02ba
DOI: 10.1101/2024.12.31.630897

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