Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge

Abstract excerpt

<title>Abstract</title> <p>The ongoing circulation of influenza A H5N1 in the United States has raised concerns of a pandemic caused by highly pathogenic avian influenza. Although the United States has stockpiled and is prepared to produce millions of vaccine doses to address an H5N1 pandemic, the currently circulating influenza A H5N1 contains multiple mutations within the immunodominant head domain of HA compar...

Topics

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• Animal Virus Infections Studies
• Coccidia and coccidiosis research
• Immune Response and Inflammation
• Influenza Virus Research Studies
• interferon and immune responses
• Respiratory viral infections research
• Viral gastroenteritis research and epidemiology
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

283ca77e-dd24-53bf-b8b5-4463c809e58e

DOI

10.21203/rs.3.rs-4946897/v1