Emergence of Antigenic Variants in Bovine H5N1 Influenza Viruses.

doi:10.1002/jmv.70394

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Article

Emergence of Antigenic Variants in Bovine H5N1 Influenza Viruses.

Journal of medical virology - 1 May 2025

Miyakawa Kei, Ota Makoto, Sano Kaori, Momose Fumitaka, Kishida Noriko, Arita Tomoko, Suzuki Yasushi, Shirakura Masayuki, Asanuma Hideki, Watanabe Shinji, Hasegawa Hideki

Abstract excerpt

The recent emergence of the H5N1 influenza virus in dairy cattle has raised significant public health concerns. Using a previously established pseudovirus-based neutralization assay, we evaluated the impact of emerging hemagglutinin (HA) mutations on the efficacy of current candidate vaccine viruses (CVVs). Neutralization analysis revealed that the cow-derived H5N1 virus showed up to a 2.2-fold reduction in...

Read the complete abstract on PubMed

Topics

Animals
Cattle
Antigenic Variation
Hemagglutinin Glycoproteins, Influenza Virus
Antibodies, Viral
Influenza A Virus, H5N1 Subtype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Antibodies, Neutralizing

Neutralization Tests

Antigens, Viral

Orthomyxoviridae Infections

Mutation

Cattle Diseases

Mutation, Missense

Source

Open in PubMed

Identifiers

PMID: 40365787
DOI: 10.1002/jmv.70394

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