Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pre-Clinical Evaluation of a Replication-Competent Recombinant Adenovirus Serotype 4 Vaccine Expressing Influenza H5 Hemagglutinin

17 Feb 2012

Abstract excerpt

BACKGROUND: Influenza virus remains a significant health and social concern in part because of newly emerging strains, such as avian H5N1 virus. We have developed a prototype H5N1 vaccine using a recombinant, replication-competent Adenovirus serotype 4 (Ad4) vector, derived from the U.S. military Ad4 vaccine strain, to express the hemagglutinin (HA) gene from A/Vietnam/1194/2004 influenza virus (Ad4-H5-Vtn). Our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Influenza Virus Research Studies
Share to interferon and immune responses
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22363572
DOI: 10.1371/journal.pone.0031177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pre-Clinical Evaluation of a Replication-Competent Recombinant Adenovirus Serotype 4 Vaccine Expressing Influenza H5 HemagglutininPMID 22363572Read ↗

A single oral immunization with a replication-competent adenovirus-vectored vaccine protects mice from influenza respiratory infectionSemantic proximity Read ↗

A Highly Protective Clade 1 and 2 Cross-Reactive Pandemic Influenza Virus Vaccine Based on a 4th Generation Fully Deleted Adenoviral Vector of a Rare SerotypeSemantic proximity Read ↗

Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challengeSemantic proximity Read ↗

Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A AntigensSemantic proximity Read ↗

Immunization of Chickens with Newcastle Disease Virus Expressing H5 Hemagglutinin Protects against Highly Pathogenic H5N1 Avian Influenza VirusesSemantic proximity Read ↗

A Reassortment-Incompetent Live Attenuated Influenza Virus Vaccine for Protection against Pandemic Virus StrainsSemantic proximity Read ↗

Adenovirus vector-based multi-epitope vaccine provides partial protection against H5, H7, and H9 avian influenza virusesSemantic proximity Read ↗

Recombinant Modified Vaccinia Virus Ankara Expressing the Hemagglutinin Gene Confers Protection against Homologous and Heterologous H5N1 Influenza Virus Infections in MacaquesSemantic proximity Read ↗

Recombinant Influenza VaccinesSemantic proximity Read ↗

Development of a new candidate H5N1 avian influenza virus for pre‐pandemic vaccine productionSemantic proximity Read ↗

Immunogenicity and Protective Efficacy of a Live Attenuated H5N1 Vaccine in Nonhuman PrimatesSemantic proximity Read ↗

Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine ResponsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.