Article

HssS activation by membrane heme defines a paradigm for 2-component system signaling in <i>Staphylococcus aureus</i>

2022-11-07

Abstract excerpt

Strict management of intracellular heme pools, which are both toxic and beneficial, can be crucial for bacterial survival during infection. The human pathogen Staphylococcus aureus uses a two-component heme sensing system (HssRS), which counteracts environmental heme toxicity by triggering expression of the efflux transporter HrtBA. The HssS heme sensor is a HisKA-type histidine kinase, characterized as a membran...

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Literature Corpus work: 11aa3733-c8be-54ad-8787-93015f170093
DOI: 10.1101/2022.11.03.515132

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