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Article

<i>Staphylococcus aureus</i> secretes a unique class of neutrophil serine protease inhibitors

26 Aug 2014

Abstract excerpt

Neutrophils are indispensable for clearing infections with the prominent human pathogen Staphylococcus aureus. Here, we report that S. aureus secretes a family of proteins that potently inhibits the activity of neutrophil serine proteases (NSPs): neutrophil elastase (NE), proteinase 3, and cathepsin G. The NSPs, but not related serine proteases, are specifically blocked by the extracellular adherence protein...

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PMID: 25161283
DOI: 10.1073/pnas.1407616111

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