Article

UFMylation anchors splicing factors at the ER to reprogram nuclear splicing

2026-03-30

Abstract excerpt

How organelles communicate stress to the nucleus to coordinate adaptive responses remains a fundamental question in cell biology. Here, we identify a non-canonical retrograde signaling pathway in which stalling-induced UFMylation of ER-associated ribosomes anchors splicing regulators at the ER, directly coupling translational stress to nuclear RNA processing. Phylogenetic profiling linked the UFMylation machinery...

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Literature Corpus work: 27d3e71a-9e96-50c0-9100-9a57beaa5da9
DOI: 10.64898/2026.03.30.715226

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