Article

Combined effects of matrix stiffness and obesity-associated signaling directs progressive phenotype in PANC-1 pancreatic cancer cells <i>in vitro</i>

2024-06-14

Abstract excerpt

<h4>ABSTRACT</h4> Obesity is a leading risk factor of pancreatic ductal adenocarcinoma (PDAC) that contributes to poor disease prognosis and outcomes. Retrospective studies have identified this link, but interactions surrounding obesity and PDAC are still unclear. Research has shifted to contributions of fibrosis (desmoplasia) on malignancy, which involves increased deposition of collagens and other extracellular...

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Literature Corpus work: 27c4b7d4-8283-5d74-bf9b-130dd3e56141
DOI: 10.1101/2024.06.11.598541

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