Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A 3D patternoid model for the reproducible characterization of invasive phenotypes and drug sensitivity in PDAC.

Lab on a chip - 8 Jul 2025

Kurzbach Sophie C, Carvajal-Heckele Violetta, Teshima Tetsuhiko F, Reichert Maximilian, Bausch Andreas R

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive and heterogeneous malignancy, posing challenges for reproducible modeling and functional phenotypic analysis. To address these limitations, we developed a standardized 3D patternoid platform using collagen-based microcavity arrays to enhance organoid formation consistency and quantify subtype-specific invasion mechanisms. We utilized murine primary PDAC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Epithelial-Mesenchymal Transition

Share to Neoplasm Invasiveness

Share to Organoids

Share to Pancreatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 40534545
DOI: 10.1039/d5lc00203f
PMCID: PMC12177931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A 3D patternoid model for the reproducible characterization of invasive phenotypes and drug sensitivity in PDAC.PMID 40534545Read ↗

Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasionSemantic proximity Read ↗

Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Phenotypic Heterogeneity and Plasticity of Cancer Cell Migration in a Pancreatic Tumor Three-Dimensional Culture ModelSemantic proximity Read ↗

Engineered extracellular matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoidsSemantic proximity Read ↗

A pancreatic cancer organoid-in-matrix platform shows distinct sensitivities to T cell killingSemantic proximity Read ↗

Form Follows Function: A New Paradigm of Pancreatic Cancer ProgressionSemantic proximity Read ↗

Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical OutcomeSemantic proximity Read ↗

An Engineered Paper-Based 3D Coculture Model of Pancreatic Cancer to Study the Impact of Tissue Architecture and Microenvironmental Gradients on Cell Phenotype.Semantic proximity Read ↗

Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancerSemantic proximity Read ↗

The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancerSemantic proximity Read ↗

Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysisSemantic proximity Read ↗

Engineered matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoidsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.