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Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance

2017-05-10

Abstract excerpt

<h4>BACKGROUND</h4> Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for the development of acquired resistance could enable optimization of patients’ treatment options. Clinically,...

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Literature Corpus work
27c2fd92-7993-5da1-8069-73597eba1574
DOI
10.1101/136564
Open publication

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Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistanceDOI 10.1101/136564
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