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Article

H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase

10 Aug 2023

Abstract excerpt

AIMS: Drivers of the drug tolerant proliferative persister (DTPP) state have not been well investigated. Histone H3 lysine-4 trimethylation (H3K4me3), an active histone mark, might enable slow cycling drug tolerant persisters (DTP) to regain proliferative capacity. This study aimed to determine H3K4me3 transcriptionally active sites identifying a key regulator of DTPPs. METHODS: Deploying a model of adaptive...

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PMID: 37639774
DOI: 10.1016/j.drup.2023.100993

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