Article

Human pluripotent stem cell-derived macrophages modify development of human kidney organoids

2025-11-08

Abstract excerpt

<h4>Introduction</h4> The human fetal kidney contains macrophages, innate immune cells postulated to enhance its development. Macrophages have also been implicated in the pathobiology of human kidney malformations and Wilms tumour. Human pluripotent stem cell (hPSC)-derived kidney organoids contain nephrons differentiated from intermediate mesoderm-like precursors. Endothelia are present between organoid tubules...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dc99650a-6837-5d61-99c2-4dd24cb8aae9
DOI: 10.1101/2025.11.07.687192

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human pluripotent stem cell-derived macrophages modify development of human kidney organoidsDOI 10.1101/2025.11.07.687192Read

Macrophages induce stromal differentiation and endothelialization in iPSC-derived kidney organoidsSemantic proximity Read

Maturation of Nephrons by Implanting hPSC-Derived Kidney Progenitors Under Kidney Capsules of Unilaterally Nephrectomized MiceSemantic proximity Read

Towards Modelling Genetic Kidney Diseases with Human Pluripotent Stem Cells.Semantic proximity Read

Developmental role of macrophages modelled in human pluripotent stem cell derived intestinal tissueSemantic proximity Read

A simple bioreactor-based method to generate kidney organoids from pluripotent stem cellsSemantic proximity Read

A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem CellsSemantic proximity Read

Human pluripotent stem cell-derived kidney organoids: Current progress and challengesSemantic proximity Read

A developmentally-inspired hypoxia condition promotes kidney organoid differentiation from human pluripotent stem cellsSemantic proximity Read

Macrophages in the kidney in health, injury and repair.Semantic proximity Read

Yolk-Sac-Derived Macrophages Progressively Expand in the Mouse Kidney with AgeSemantic proximity Read

The Aorta-Gonad-Mesonephros niche shapes the functions of yolk sac-derived macrophages involved in hematopoietic stem and progenitor cell generation <i>ex vivo</i>Semantic proximity Read

Unlocking the full potential of human pluripotent stem cell–derived kidney organoids through bioengineeringSemantic proximity Read