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Article

Role of Epigenetic Histone Modifications in Diabetic Kidney Disease Involving Renal Fibrosis

1 Jan 2017

Abstract excerpt

One of the commonest causes of end-stage renal disease is diabetic kidney disease (DKD). Renal fibrosis, characterized by the accumulation of extracellular matrix (ECM) proteins in glomerular basement membranes and the tubulointerstitium, is the final manifestation of DKD. The TGF-βpathway triggers epithelial-to-mesenchymal transition (EMT), which plays a key role in the accumulation of ECM proteins in DKD....

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PMID: 28695133
DOI: 10.1155/2017/7242384

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