Article

An fMRI Phenotype of Reward in Effort Expenditure in the VTA and Dorsal Raphe: A Longitudinal Study of Depression under Escitalopram Treatment

2026-07-27

Abstract excerpt

Anhedonia and motivational impairment are central features of major depressive disorder, yet the neural processes linking reward information to sustained goal-directed behaviour remain insufficiently understood. Using functional magnetic resonance imaging, we examined representations of reward levels during sustained effort expenditure (a construct in the RDoc framework) as a distinct component of reward processin...

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Literature Corpus work: 27af944e-42c1-5ca9-938c-1d5e9cb5d229
DOI: 10.64898/2026.07.24.26358864

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An fMRI Phenotype of Reward in Effort Expenditure in the VTA and Dorsal Raphe: A Longitudinal Study of Depression under Escitalopram TreatmentDOI 10.64898/2026.07.24.26358864Read

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