Article
Computational Phenotyping of Effort-Based Decision Making in Unmedicated Adults With Remitted Depression.
Biological psychiatry. Cognitive neuroscience and neuroimaging - 1 Jun 2025
Kuhn Manuel, Palermo Emma H, Pagnier Guillaume, Blank Jacob M, Steinberger David C, Long Yinru, Nowicki Genevieve, Cooper Jessica A, Treadway Michael T, Frank Michael J, Pizzagalli Diego A
Abstract excerpt
BACKGROUND: Reduced motivation is a core feature of major depressive disorder (MDD). Yet, the extent to which this deficit persists in remitted MDD (rMDD) remains unclear. Here, we examined effort-based decision making as one aspect of amotivation in rMDD using computational phenotyping to characterize decision-making processes and strategies. METHODS: Unmedicated adults with rMDD (n = 40) and healthy control...
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