Article

Identification of a Broadly Acting Inhibitor of the Alphavirus Non-Structural Protein 2 Helicase

2025-06-04

Abstract excerpt

Alphaviruses are mosquito-borne viruses that have caused significant outbreaks in the 21 st century. Despite multiple recent outbreaks, there are no approved antiviral drugs to treat any alphavirus infection. Therefore, developing broadly acting antiviral drugs effective against multiple alphaviruses is necessary and could provide protection from both current and emerging alphavirus threats. A critical component...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 279a23c5-43aa-5558-983d-f58c2bb31851
DOI: 10.1101/2025.06.03.657755

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of a Broadly Acting Inhibitor of the Alphavirus Non-Structural Protein 2 HelicaseDOI 10.1101/2025.06.03.657755Read

Alphavirus nsP2: A Multifunctional Regulator of Viral Replication and Promising Target for Anti‐Alphavirus TherapiesSemantic proximity Read

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitorSemantic proximity Read

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitorSemantic proximity Read

Identification and Characterization of Novel Chikungunya Virus Polymerase InhibitorsSemantic proximity Read

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2Semantic proximity Read

Therapeutic potential of compounds targeting SARS-CoV-2 helicaseSemantic proximity Read

Structural insights into RNA recognition by the Chikungunya virus nsP2 helicaseSemantic proximity Read

Emetine dihydrochloride inhibits Chikungunya virus nsP2 helicase and shows antiviral activity in the cell culture and mouse model of virus infectionSemantic proximity Read

The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infectionSemantic proximity Read

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 HelicaseSemantic proximity Read

Functional Cross-talk between Distant Domains of Chikungunya Virus Non-structural Protein 2 Is Decisive for Its RNA-modulating ActivitySemantic proximity Read

Novel Computational Pipeline to Identify Target Sites for Broad Spectrum Antiviral DrugsSemantic proximity Read