Article

Novel Computational Pipeline to Identify Target Sites for Broad Spectrum Antiviral Drugs

2025-07-30

Abstract excerpt

Emerging viruses pose an ongoing threat to human health. While certain viral families are common sources of outbreaks, predicting the specific virus within a family that will cause the next outbreak or pandemic is not possible, creating an urgent need for broad spectrum antiviral drugs that are effective against an array of related viral pathogens. However, broad spectrum drug development is hindered by the lack o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb4eede1-20a4-5ead-bf5d-515331cac1ca
DOI: 10.1101/2025.07.30.667737

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel Computational Pipeline to Identify Target Sites for Broad Spectrum Antiviral DrugsDOI 10.1101/2025.07.30.667737Read

The SARS-CoV-2 replication-transcription complex is a priority target for broad-spectrum pan-coronavirus drugsSemantic proximity Read

A Structure-Based Computational Pipeline for Broad-Spectrum Antiviral DiscoverySemantic proximity Read

Conserved Filovirus Proteins as Targets of Broad-Spectrum AntiviralsSemantic proximity Read

Integrated Docking and Enhanced Sampling Based Selection of Repurposing Drugs for SARS-CoV-2 by Targeting Host Dependent FactorsSemantic proximity Read

High Throughput Virtual Screening and Validation of a SARS-CoV-2 Main Protease Non-Covalent InhibitorSemantic proximity Read

Genetic Variability of the SARS-CoV-2 PocketomeSemantic proximity Read

Zika virus NS5 protein potential inhibitors: an enhanced in silico approach in drug discoverySemantic proximity Read

Virtual screening FDA approved drugs against multiple targets of SARS‐CoV‐2Semantic proximity Read

Identification of novel transmembrane Protease Serine Type 2 drug candidates for COVID-19 using computational studiesSemantic proximity Read

Structure-based drug repurposing targeting pathogenic virus superfamily 1 helicase: An integrated multi-computational screening and bioactivity identification strategySemantic proximity Read

Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray ScreeningSemantic proximity Read

Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallographySemantic proximity Read