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The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection

22 Aug 2016

Abstract excerpt

The chikungunya virus (CHIKV) has become a substantial global health threat due to its massive re-emergence, the considerable disease burden and the lack of vaccines or therapeutics. We discovered a novel class of small molecules ([1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones) with potent in vitro activity against CHIKV isolates from different geographical regions. Drug-resistant variants were selected and these...

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PMID: 27545976
DOI: 10.1038/srep31819

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