Article

Emetine dihydrochloride inhibits Chikungunya virus nsP2 helicase and shows antiviral activity in the cell culture and mouse model of virus infection

2025-06-20

Abstract excerpt

<h4>ABSTRACT</h4> Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes frequent epidemics of chikungunya fever across the world and has become a significant medical challenge, warranting the development of novel antivirals. A cell imaging-based high-content screening of the Spectrum collection of small molecules, containing all the US and international drug molecules, identified Emetine dihydrochloride...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d2f86d20-f4eb-56ec-9aff-c76bb770b800
DOI: 10.1101/2025.06.20.660672

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Emetine dihydrochloride inhibits Chikungunya virus nsP2 helicase and shows antiviral activity in the cell culture and mouse model of virus infectionDOI 10.1101/2025.06.20.660672Read

Identification and Characterization of Novel Chikungunya Virus Polymerase InhibitorsSemantic proximity Read

Chikungunya virus: an update on antiviral development and challengesSemantic proximity Read

Chikungunya virus drug discovery: still a long way to go?Semantic proximity Read

Drug repurposing approach against chikungunya virus: an in vitro and in silico studySemantic proximity Read

Defective viral genomes from chikungunya virus are broad-spectrum antivirals and prevent virus dissemination in mosquitoesSemantic proximity Read

Characterization of β- d - N 4 -Hydroxycytidine as a Novel Inhibitor of Chikungunya VirusSemantic proximity Read

Drugs targeting structural and nonstructural proteins of the chikungunya virus: A reviewSemantic proximity Read

Neuropilin-1 functions as a proviral and immunoregulatory host factor during Chikungunya virus infectionSemantic proximity Read

Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping MachinerySemantic proximity Read

In silico identification of chikungunya virus replication inhibitor validated using biochemical and cell‐based approachesSemantic proximity Read

Inhibition of early RNA replication in Chikungunya and Dengue virus by lycorine: In vitro and in silico studiesSemantic proximity Read

Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infectionSemantic proximity Read