Article

Tumor- and Nerve-Derived Axon Guidance Molecule Promotes Pancreatic Ductal Adenocarcinoma Progression and Metastasis through Macrophage Reprogramming

2023-10-27

Abstract excerpt

<h4>ABSTRACT</h4> Axon guidance molecules were found to be the gene family most frequently altered in pancreatic ductal adenocarcinoma (PDA) through mutations and copy number changes. However, the exact molecular mechanism regarding PDA development remained unclear. Using genetically engineered mouse models to examine one of the axon guidance molecules, semaphorin 3D (SEMA3D), we found a dual role for tumor-deriv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2791434c-f48f-58e2-a191-9ea1f6097238
DOI: 10.1101/2023.10.24.563862

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tumor- and Nerve-Derived Axon Guidance Molecule Promotes Pancreatic Ductal Adenocarcinoma Progression and Metastasis through Macrophage ReprogrammingDOI 10.1101/2023.10.24.563862Read

The axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDACSemantic proximity Read

Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC.Semantic proximity Read

The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in pancreatic cancerSemantic proximity Read

Roles of the nervous system in pancreatic cancerSemantic proximity Read

Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion.Semantic proximity Read

Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1Semantic proximity Read

Reprogrammed Schwann Cells Organize into Dynamic Tracks that Promote Pancreatic Cancer InvasionSemantic proximity Read

Mind the (guidance) signals! Translational relevance of semaphorins, plexins, and neuropilins in pancreatic cancerSemantic proximity Read

Integrated transcriptional analysis reveals macrophage heterogeneity and tumor-macrophage interactions in the progression of pancreatic ductal adenocarcinomaSemantic proximity Read

SEMA5A-PLXNB3 axis promotes PDAC liver metastasis outgrowth through enhancing Warburg effectSemantic proximity Read

Spatial Transcriptomics Reveals Novel Mechanisms Involved in Perineural Invasion in Pancreatic Ductal AdenocarcinomasSemantic proximity Read

Whole Genome Sequencing of Newly Established Pancreatic Cancer Lines Identifies Novel Somatic Mutation (c.2587G>A) in Axon Guidance Receptor Plexin A1 as Enhancer of Proliferation and Invasion.Semantic proximity Read