Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC.

doi:10.1136/gutjnl-2023-329807

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC.

Gut - 11 Jul 2024

Lupo Francesca, Pezzini Francesco, Pasini Davide, Fiorini Elena, Adamo Annalisa, Veghini Lisa, Bevere Michele, Frusteri Cristina, Delfino Pietro, D'agosto Sabrina, Andreani Silvia, Piro Geny, Malinova Antonia, Wang Tian, De Sanctis Francesco, Lawlor Rita Teresa, Hwang Chang-Il, Carbone Carmine, Amelio Ivano, Bailey Peter, Bronte Vincenzo, Tuveson David, Scarpa Aldo, Ugel Stefano, Corbo Vincenzo

Abstract excerpt

OBJECTIVE: The dysregulation of the axon guidance pathway is common in pancreatic ductal adenocarcinoma (PDAC), yet our understanding of its biological relevance is limited. Here, we investigated the functional role of the axon guidance cue SEMA3A in supporting PDAC progression. DESIGN: We integrated bulk and single-cell transcriptomic datasets of human PDAC with in situ hybridisation analyses of patients'...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Cell Movement

Share to Mice

Share to Neuropilin-1

Share to Pancreatic Neoplasms

Share to Phenotype

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 38670629
DOI: 10.1136/gutjnl-2023-329807
PMCID: PMC11287654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC.PMID 38670629Read ↗

The axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDACSemantic proximity Read ↗

Tumor- and Nerve-Derived Axon Guidance Molecule Promotes Pancreatic Ductal Adenocarcinoma Progression and Metastasis through Macrophage ReprogrammingSemantic proximity Read ↗

Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancerSemantic proximity Read ↗

GNA15 signaling facilitates the initial phases of pancreas cell transformation and is associated with the basal-like/squamous subtypeSemantic proximity Read ↗

A mucus production programme promotes classical pancreatic ductal adenocarcinomaSemantic proximity Read ↗

A GATA6-centred gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancerSemantic proximity Read ↗

Spatial Transcriptomics Reveals Novel Mechanisms Involved in Perineural Invasion in Pancreatic Ductal AdenocarcinomasSemantic proximity Read ↗

SEMA3C Supports Pancreatic Cancer Progression by Regulating the Autophagy Process and Tumor Immune MicroenvironmentSemantic proximity Read ↗

The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in pancreatic cancerSemantic proximity Read ↗

Mind the (guidance) signals! Translational relevance of semaphorins, plexins, and neuropilins in pancreatic cancerSemantic proximity Read ↗

Invasion status stratifies the composition of the human pancreatic cancer perineural nicheSemantic proximity Read ↗

Whole Genome Sequencing of Newly Established Pancreatic Cancer Lines Identifies Novel Somatic Mutation (c.2587G>A) in Axon Guidance Receptor Plexin A1 as Enhancer of Proliferation and Invasion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.