Article

Reprogrammed Schwann Cells Organize into Dynamic Tracks that Promote Pancreatic Cancer Invasion

2022-03-08

Abstract excerpt

<h4>ABSTRACT</h4> Nerves are a component of the tumor microenvironment contributing to cancer progression, but the role of cells from nerves in facilitating cancer invasion remains poorly understood. Here we show that Schwann cells (SCs) activated by cancer cells collectively function as Tumor Activated Schwann cell Tracks (TASTs) that promote cancer cell migration and invasion. Non-myelinating SCs form TASTs and...

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Literature Corpus work: df04f663-24fc-50f1-8884-8567405b74db
DOI: 10.1101/2022.03.08.481473

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