Back to search

Article

Epigenetics of Aging in Mammals: Mechanistic Foundations and Intervention Effects on DNA Methylation–Based Aging Biomarkers

2026-03-10

Abstract excerpt

<h4>Background: </h4> Aging is shaped by interdependent molecular processes captured by the hallmarks framework, in which epigenetic alterations stand out as a potentially modifiable regulatory layer. DNA methylation (DNAm) patterns change with age and can be summarized by epigenetic clocks that estimate biological age, pace of aging, and risk-related phenotypes. Yet, the extent to which interventions reproducibly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
786069be-0209-5fbc-9cb6-b73b08a0eee4
DOI
10.20944/preprints202603.0713.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Epigenetics of Aging in Mammals: Mechanistic Foundations and Intervention Effects on DNA Methylation–Based Aging BiomarkersDOI 10.20944/preprints202603.0713.v1
The Sociodemographic and Lifestyle Correlates of Epigenetic Aging in a Nationally Representative U.S. Study of Younger AdultsSemantic proximity
The Epigenetic Landscape: From Molecular Mechanisms to Biological AgingSemantic proximity
Human Aging DNA Methylation Signatures are Conserved but Accelerated in Cultured FibroblastsSemantic proximity
Epigenetic Clocks: In Aging-Related and Complex DiseasesSemantic proximity
How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life SpanSemantic proximity
Stress, diet, exercise: Common environmental factors and their impact on epigenetic ageSemantic proximity
Epigenetic Clock: DNA Methylation as a Marker of Biological Age and Age-Associated DiseasesSemantic proximity
The use of DNA methylation clock in aging research.Semantic proximity
Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblastsSemantic proximity
Current perspectives on the cellular and molecular features of epigenetic ageingSemantic proximity
DNA methylation : a model system for the study of ageingSemantic proximity
Social determinants of health and epigenetic clocks: Meta-analysis of 140 studiesSemantic proximity
Select a neighboring publication to make it the new centre.