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Interplay of IL6 and CRIM1 on thiopurine-induced neutropenia in leukemic patients with wild-type NUDT15 and TPMT

2020-07-25

Abstract excerpt

<h4>Background</h4> NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity. Despite recent discovery of homozygous CRIM1 effect on thiopurine toxicity, many patients with wild-type NUDT15, TPMT , and CRIM1 still suffer from thiopurine toxicity, and therapeutic failure and relapse of acute lymphoblastic leukemia (ALL). <h4>Methods</h4> Novel PGx interactions associated...

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Identifiers and source

Literature Corpus work
2782dc19-4c3f-5146-b1c8-40473cb10941
DOI
10.1101/2020.07.21.20158931
Open publication

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