Article

Optimized nanoparticle-mediated delivery of CRISPR-Cas9 system for B cell intervention

2018-08-01

Abstract excerpt

B cells exert multiple effector functions, and dysfunctions of B cells often lead to initiation and progression of diseases, including autoimmune and inflammatory diseases. Therefore, B cell intervention may be an effective strategy to treat diseases involving B cells. The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 gene editing system has been widely used for DNA deletion, insertion, a...

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Literature Corpus work: 33683815-8e55-5f72-96d0-ac63c6275c2f
DOI: 10.1007/s12274-018-2150-5

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