Article
Dysfunctional phenotype of systemic and pulmonary regulatory T cells associate with lethal COVID-19 cases.
Immunology - 1 Apr 2023
Gonçalves-Pereira Marcela Helena, Santiago Luciana, Ravetti Cecilia Gómez, Vassallo Paula Frizera, de Andrade Marcus Vinicius Melo, Vieira Mariana Sousa, de Fátima Souza de Oliveira Fernanda, Carobin Natália Virtude, Li Guangzhao, de Paula Sabino Adriano, Nobre Vandack, da Costa Santiago Helton
Abstract excerpt
Severe cases of COVID-19 present hyperinflammatory condition that can be fatal. Little is known about the role of regulatory responses in SARS-CoV-2 infection. In this study, we evaluated the phenotype of regulatory T cells in the blood (peripheral blood mononuclear cell) and the lungs (broncho-alveolar) of adult patients with severe COVID-19 under invasive mechanical ventilation. Our results show important...
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