Article

Regulatory T-cells are central hubs for age-, sex- and severity-associated cellular networks during COVID-19

2022-01-06

Abstract excerpt

Using single-cell proteomics by mass cytometry, we investigate changes to a broad selection of over 10,000,000 immune cells in a cohort of moderate, severe, and critical Japanese COVID-19 patients and healthy controls with a particular focus on regulatory T-cells (Tregs). We find significant disruption within all compartments of the immune system and the emergence of atypical CTLA-4 high CD4 T-cells and proliferat...

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Literature Corpus work: 75d3ae70-f065-555f-9210-648715fc7ce5
DOI: 10.1101/2022.01.06.22268711

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