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Article

E2F1-induced autocrine IL-6 inflammatory loop mediates cancer-immune crosstalk that predicts T cell phenotype switching and therapeutic responsiveness.

Frontiers in immunology - 1 Jan 2024

Spitschak Alf, Dhar Prabir, Singh Krishna P, Garduño Rosaely Casalegno, Gupta Shailendra K, Vera Julio, Musella Luca, Murr Nico, Stoll Anja, Pützer Brigitte M

Abstract excerpt

Melanoma is a metastatic, drug-refractory cancer with the ability to evade immunosurveillance. Cancer immune evasion involves interaction between tumor intrinsic properties and the microenvironment. The transcription factor E2F1 is a key driver of tumor evolution and metastasis. To explore E2F1's role in immune regulation in presence of aggressive melanoma cells, we established a coculture system and utilized...

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Identifiers

PMID: 39544930
DOI: 10.3389/fimmu.2024.1470368
PMCID: PMC11560763

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