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Article

Melanoma stem cells drive macrophage reprogramming to a hybrid phenotype, modulating melanoma stemness and compromising NK cell-mediated immunity.

Frontiers in immunology - 1 Jan 2026

Anselmi Martina, Francesconi Michela, Triulzi Tiziana, Bernardo Giancarla, Le Noci Valentino, Bianchi Francesca, Castagnoli Lorenzo, Arnaboldi Francesca, Gagliano Nicoletta, Pupa Serenella M, Limonta Patrizia, Sfondrini Lucia, Sommariva Michele

Abstract excerpt

Introduction: Melanoma stem cells may contribute to tumor progression not only through intrinsic plasticity, but also by shaping the immune microenvironment. However, their interaction with the monocyte-macrophage compartment remains poorly understood. Methods: Melanosphere cultures derived from A375 and WM115 melanoma cell lines were used as an in vitro model enriched for stemness-associated features. THP-1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42311672
DOI: 10.3389/fimmu.2026.1698412
PMCID: PMC13269258

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CCR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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