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Article

New insights into the pathophysiology and development of novel therapies for sickle cell disease

30 Nov 2018

Abstract excerpt

Although the seminal event in sickle cell disease is the polymerization of abnormal hemoglobin, the downstream pathophysiology of vasoocclusion results from heterotypic interactions between the altered, adhesive sickle cell red blood cells, neutrophils, endothelium, and platelets. Ischemia reperfusion injury, hemolysis, and oxidant damage all contribute to heightened inflammation and activation of the hemostatic...

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PMID: 30504350
DOI: 10.1182/asheducation-2018.1.493

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