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Article

Decoding the role of SOD2 in sickle cell disease

10 Sept 2019

Abstract excerpt

Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a single point mutation in the β-globin gene. As a consequence, deoxygenated hemoglobin polymerizes triggering red blood cell sickling and hemolysis, vaso-occlusion, and ischemia/reperfusion. Allied to these pathologies is the overproduction of reactive oxygen species driven by hemoglobin Fenton chemistry and peroxidase reactions as well as by...

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PMID: 31506286
DOI: 10.1182/bloodadvances.2019000527

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