Article

Kaempferol enhances ER-mitochondria coupling and protects motor neurons from ER stress and mitochondrial dysfunction in C9ORF72- ALS

2024-12-19

Abstract excerpt

<title>Abstract</title> Repeat expansions in the <italic>C9ORF72</italic> gene are a frequent cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Considerable progress has been made in identifying <italic>C9ORF72</italic>-mediated disease and resolving its underlying etiopathogenesis. The contributions of intrinsic mitochondrial deficits as well as chronic endoplasmic reticulum stress to...

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Literature Corpus work: 26bbc05a-175e-5bdf-a4ef-c6f5c2795eb4
DOI: 10.21203/rs.3.rs-5190511/v1

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