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Poly(GR) in C9ORF72 -Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons

1 Oct 2016

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PMID: 27720481
DOI: 10.1016/j.neuron.2016.09.015

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Poly(GR) in C9ORF72 -Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor NeuronsPMID 27720481Read ↗

C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivoSemantic proximity Read ↗

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RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense InterventionSemantic proximity Read ↗

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A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypesSemantic proximity Read ↗

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A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes.Semantic proximity Read ↗

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