Article

Impact on backpropagation of the spatial heterogeneity of sodium channel kinetics in the axon initial segment

2022-04-05

Abstract excerpt

In a variety of neurons, action potentials (APs) initiate at the proximal axon, within a region called the axon initial segment (AIS), which has a high density of voltage-gated sodium channels (Na V s) on its membrane. In pyramidal neurons, the proximal AIS has been reported to exhibit a higher proportion of Na V s with gating properties that are “ right-shift ed” to more depolarized voltages, compared to the d...

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Literature Corpus work: 2ea5ebd8-b679-559c-bcb0-3a9ccfe8db3e
DOI: 10.1101/2022.04.01.486760

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