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ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ

15 Mar 2021

Abstract excerpt

Previously, we identified missense mutations in CCNF that are causative of familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Hallmark features of these diseases include the build-up of insoluble protein aggregates as well as the mislocalization of proteins such as transactive response DNA binding protein 43 kDa (TDP-43). In recent years, the dysregulation of SFPQ...

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PMID: 33729478
DOI: 10.1093/hmg/ddab073

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ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQPMID 33729478Read ↗

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