Article

Retrograde transport defects in <i>Munc18-1</i> null neurons explain abnormal Golgi morphology

2020-05-13

Abstract excerpt

Loss of the exocytic Sec1/MUNC18 protein MUNC18-1 or its t-SNARE partners SNAP25 and syntaxin-1 results in rapid, cell-autonomous and unexplained neurodegeneration, which is independent of their known role in synaptic vesicle exocytosis. cis- Golgi abnormalities are the earliest cellular phenotypes before degeneration occurs. Here, we investigated whether these Golgi abnormalities cause defects in the constitutiv...

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Literature Corpus work: 163405ea-9cf1-5828-9711-cd8142b28b94
DOI: 10.1101/2020.05.12.090811

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