Article

BioID analysis of the cyclin F interactome reveals that ALS-variant cyclin F alters the homeostasis of paraspeckle-associated proteins

2020-05-01

Abstract excerpt

<h4>Background</h4> Previously, we identified missense mutations in CCNF that are causative of familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). CCNF encodes for the protein cyclin F, a substrate recognition component of the E3-ubiquitin ligase, SCF cyclin F . We have previously shown that mutations in CCNF cause disruptions to overall protein homeostasis; causing a...

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Literature Corpus work: 91205e9b-d8f0-5d44-9d5e-e64b793f513d
DOI: 10.1101/2020.04.30.071365

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