Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Cyclin F, Neurodegeneration, and the Pathogenesis of ALS/FTD.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry - 1 Apr 2024

Rayner Stephanie L, Hogan Alison, Davidson Jennilee M, Cheng Flora, Luu Luan, Morsch Marco, Blair Ian, Chung Roger, Lee Albert

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease and is characterized by the degeneration of upper and lower motor neurons of the brain and spinal cord. ALS is also linked clinically, genetically, and pathologically to a form of dementia known as frontotemporal dementia (FTD). Identifying gene mutations that cause ALS/FTD has provided valuable insight into the disease process....

Topics

Join the communities discussing this publication.

Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis Research
Cyclins
Frontotemporal Dementia
Motor Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurogenetic and Muscular Disorders Research

Prion Diseases and Protein Misfolding

Source

Identifiers

PMID: 36062310
DOI: 10.1177/10738584221120182

Genes

CCNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclin F, Neurodegeneration, and the Pathogenesis of ALS/FTD.PMID 36062310Read ↗

ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQSemantic proximity Read ↗

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.Semantic proximity Read ↗

The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis.Semantic proximity Read ↗

BioID analysis of the cyclin F interactome reveals that ALS-variant cyclin F alters the homeostasis of paraspeckle-associated proteinsSemantic proximity Read ↗

TDP-43 is a ubiquitylation substrate of the SCFcyclin F complexSemantic proximity Read ↗

ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis.Semantic proximity Read ↗

ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi trafficking, inducing ER stress, ERAD and Golgi fragmentation.Semantic proximity Read ↗

Pathogenic mutations in the ALS gene CCNF cause cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase activitySemantic proximity Read ↗

The Molecular Intersection of NEK1, C21ORF2, Cyclin F, and VCP in ALS PathogenesisSemantic proximity Read ↗

TDP-43 pathology and functional deficits in wild-type and ALS/FTD mutant cyclin F mouse models.Semantic proximity Read ↗

Cyclin F: A component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancerSemantic proximity Read ↗

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.